REJEON PCL Filler Injection Anti-wrinkle kusimudza uye kusimbisa
Kwakabva REJEON PCL
Mumakore makumi maviri apfuura, manzwisisiro edu eimwe yenzvimbo dzakaomesesa dzemuviri wemunhu - kumeso - kwakavandudzika zvakanyanya, paine akati wandei maumbirwo eanatomical akaonekwa.
Panguva imwecheteyo, kuwanda kwekusavhiya
nzira dzavepo dzekurapa
zviratidzo zvekukwegura uye kudzorera vechidiki
kuonekwa kwechiso. REJEON ndiye wekutanga, uye
parizvino ndiyo yega, collagen sti mulator iyo inogadzirwa nepolycaprolactone microspheres, iyo inobatsira mukusimba kwayo kwekunakisa kuwedzeredzwa. REJEON
Kusarudzika kwezvimiro zvinoreva kuti isarudzo inodiwa yemhando dzakasiyana-siyana dzezvinyama zvakapfava.
Summary
Kuumbwa kweREJ EO N ,
7 0 % aqueous CMC- yakavakirwa
gel mutakuriuye3 0% PCL
chimiro,inobvumira
kukurumidza kuzadza maitiro
inokonzerwa neCMC, ichiteverwa nekukurudzira kwemuviri wega collagen (neocollagenesis).
CMC yakadzoserwa 2 kusvika ku3
mwedzi mushure-majekiseniuye inotsiviwa zvishoma nezvishoma neyemurwere
collagen (kunyanya mhando I) inokurudzirwa ne
PCL microspheres. Iwo ma microspheres ePCL anewo bioresorbable.
REJEON ine akati wandei hunhu hunoita kuti ive inoyevedza sarudzo sedermal filler:
① Encapsulation yepolymer microspheres, mukati memwedzi 1, uye yakabatana collagen scaffold inodzivirira kumwe kuzvimba kuita kuti kurege kuitika13
②Iyo inogara collagen mhando mune jekiseni saiti ndiyo inonyanya 'kukura' collagen scaffold ye collagen mhando I5.
a) Kuderedzwa kwe collagen rudzi III zvinoreva kuti hapana kumwe kukurudzirwa kwemhinduro yekuzvimba
③Kushatiswa kwezvikamu zveREJEON kunopedzwa ne hydrolysis, kuchisiya mvura necarbon dioxide.
④Nekuti vhoriyamu yekupedzisira mukati menzvimbo yakarapwa yakakura kudarika huwandu hweEllansé jekiseni, hapana chinodiwa 'kubata' kurapwa.
a) Vhoriyamu yekupedzisira yakakura kudarika vhoriyamu yakabaiwa ne20-30% nekuda kwekuumbwa kwecollagen type I fibres11
⑤Kuwanikwa kweshanduro mbiri dzeREJEON dzine nguva dzakasiyana dzekuita zvinoreva kuti kureba kwekurapa kunogona kuenderana nemurwere.
zvinodiwa
a) Izvi zvinowanikwa nekusiyanisa kureba kwemaketani ePCL, zvichibvumira kufungidzirwa, kudzorwa uye kuchinjika bioresorption.
⑥Iyo nzira yekurapa yakafanana zvisinei kuti REJEON chigadzirwa chakasarudzwa a) Zvakafanana:
● Rheological properties
● Nzira
● Sirasi
● Tsono/cannula
REJEON PCL Yakasarudzika kuumbwa
REJEON PCL inoumbwa neyakasarudzika, ine patented
musanganiswa we:
● 7 0 % carboxymethyl cellulose (CMC) - yakavakirwa gel carrier
● 3 0% polycaprolactone (PCL) microspheres (Mufananidzo 1.4) 3, 4, 5
Iyo PCL microspheres inobatwa mukati
homogeneous kumiswa muCMC-based gel carrier. PCL neCMC zvese zvine yakanakisa uye yakaratidza biocompatibility mbiri.
REJEON PCL zvigadzirwa zvinobva kuGemany
PCL MICROSPHERES
PCL ipolyester yekurapa isiri-chepfu, yakatanga kugadzirwa mukutanga kwema1930s4, ndiko kuti.
inoyevedza yekushandiswa mune dermal fillers nekuda kwekureruka kwayo kwebioresorption; inongoitwa hydrolysed kuita kabhoni dhaikisaidhi nemvura mukati memuviri5.
Iyo PCL microspheres inoshandiswa mukati
RE JEON dzakagadzirirwa kupa
optimal biocompatibility6 . Vane nzvimbo yakatsetseka, a
spherical shape uye saizi ye
anenge 25–50 μm
PCL ine yakanakisa kuchengetedza profile3 uye yakashandiswa mumunda webiomedical kwemakore anopfuura 70 kune dzakasiyana siyana dzekushandisa, kubva kune sutures kusvika kune tishu uye organ kutsiviwa ne 3D kudhinda (Mufananidzo 1.6)4. Inoshandiswawo muEC-yakanyorwa uye US Chikafu uye
Drug Administration (FDA) - zvigadzirwa zvakabvumidzwa.
ZVINHU ZECMC
CMC chinhu chakasikwa chinobva ku cellulose; haina kubatanidzwa, uye haina chepfu. Zvimwe zvinhu zvayo zvinosanganisira (Mufananidzo 1.7)4 :
● Mushonga unozivikanwa unobatsira
● Inoita hygroscopic
● Yakasarudzwa neFDA sezvinowanzozivikanwa seyakachengeteka (GRAS)
● Resorption inoitika mumwedzi 2 - 3
Iwo akakosha mabhenefiti eREJEON PCL Filler
REJEON PCL ine yakasarudzika uye yakakwana microsphere, ine chidimbu saizi inosangana nemamiriro ekunze ekuchengetedza uye nzvimbo yakatsetseka iyo inogona kuramba ichisimudzira kukura kwecollagen.
Collagen kukurudzira naREJEON: Humbowo hwesainzi
REJEON anga ari
kuedzwa mumhuka
muenzaniso apo tsuro dzaibaiwa nawo
kana REJEON S
(PCL-1) kana REJEON M (PCL-2) kuongorora neocollagenesis5.
Mwedzi mipfumbamwe mushure mejekiseni rePCL-1,
neocollagenesis yakanga yaitika uye PCL microspheres yePCL-1 yakanga yakanyatsogadziriswa (Mufananidzo 1. 1 1) 5.
Zvichakadaro, nePCL- 2 pamwedzi 9,
pakanga paine humbowo hwekuumbwa kwe
mhando I uye nyora III collagen kumativi
PCL microspheres. Pamwedzi ye2 1 mushure mejekiseni, PCL- 2 microspheres yakanga ichiripo mune injected tissue5.
Muchidzidzo chemutyairi cheRE JEO N muvanhu, varwere vakanyoreswa kuti vagamuchire Ellansé akabayiwa intradermally mutemberi.
dunhu9 . Histological ongororo yezvinyama zvakawanikwa kubva kubiopsies zvakaratidzwa
collagen formation yakapoteredza injected PCL particles (Mufananidzo 1. 12) 9, inotsigira zvakawanikwa zvakafanana zvakaratidzwa kare
tsuro tishu5.
REJEON nzira yekuita
REJEON ine zvikamu zviviri zvakasiyana zvechiitiko (Mufananidzo 1.9)1,4 :
● Danho 1: Pakarepo mushure mejekiseni, chikamu cheCMC chinopa vhoriyamu yenguva pfupi,
iyo inoderera zvishoma nezvishoma pamusoro pemwedzi 2-3
● Danho 2: Iyo PCL microspheres inokurudzira
neocollagenesis yemhando I uye III collagen, ine inopfuurira mhando I collagen
chimiro zvishoma nezvishoma chichiwedzera pamusoro pemwedzi 1 - 3 uye PCL microspheres
kunyudzwa mumhando I collagen
scaffold. Izvo zvinokonzerwa ne collagen volume
inotsiva iyo yekutanga vhoriyamu kuwedzera kunokonzerwa neCMC gel
Iyo collagen scaffold inokurudzirwa nePCL
ma microspheres anoenderera mberi mushure mekunge adzokororwa, zvichikonzera kuwedzera kwakasimba kwevhoriyamu kunoonekwa neREJEON.
REJEON PCL Filler ine mhedzisiro yakanaka
REJEON PCL Filler ndeye yakakwira-yekupedzisira-yakareba-yekuzadza mumiriri iyo inogona kutsvedza zviteshi zvakasiiwa nenguva uye kudzoreredza chitarisiko chakapfava uye chechidiki kumeso.
REJEON PCL FILLER CUSTOMER FEEDBACK
Isu tinoda kugovera hunyanzvi hwedu uye
ruzivo munguva uye sei yekubatanidza r ej eon mukuita kwekiriniki. Ndinovimba ichabatsira muverengi nenzira imwechete yayandiitira kwemakore gumi apfuura: kupa marapirwo akachengeteka ane mhedzisiro iri nani uye mhedzisiro inogara kwenguva refu. RE JEON chishandiso chakakosha mukuita kwangu uye yakandiita jekiseni riri nani! ”
Dr Francisco de Melo
Plastic Surgeon, UAE
“RE JEON yanga iri yandaifarira dermal filler
7 years. Bhuku rino richakubatsira kugona kushandisa
RE JEON uye iwe uchawira murudo nazvo. ”
Dr Shang- Li Lin
Dermatologist, Taiwan
"Kuvandudzwa kwechimiro uye ganda
mhando inokonzerwa neRE JOE N 's yakasarudzika
neocollagenesis haina kufananidzwa. Pasina kupokana imwe yeakanakisa maturusi emakiriniki anoda yakanyanya kunyatsoshanda uye kuchengetedzeka mune injectable chigadzirwa. REJ EO N ane
kugona kupa kusimudza-kunogara kwenguva refu uye yakagadziridzwa chimiro chechiso nechikamu chimwe chete. ”
Dr Ingrid Ló pez- Gehrke
Dermatologist, Mexico
"Ini ndinowana mufaro mukuru mukushandisa RE JEON nekuda kwekushamisa kwayo vol umi kuimba maitiro. Izvi zvinobvumira zvishoma
chigadzirwa chinoshandiswa, uye kuburikidza nekugadzirwa chaiko kwe collagen mhando I, ine simba rechokwadi reganda
kuberekwa patsva. Varwere vakawanda vanondiudza kuti: ‘Inguva yokutanga
Ndine chimwe chinhu chinogara', kana 'Tarisa kunaka kweganda rangu'. Chokwadi yangu yandinoda filler. ”
Dr Pierre Nicolau
Plastic Surgeon, Spain
REJEON MAJOR MILESTONES
Kutevera tsvakiridzo yakakura uye budiriro, uye kiriniki
kuyedza, REJEON yakawana ISO 13485 Quality Management System chitupa mukati
20081 (Mufananidzo 1.2). Muna 2009, kubvumidzwa kweEuropean Conformity (CE) kwakabvumidzwa
kupiwa, kutungamirira
kusvika pakuvambwa kwakabudirira zvikuru kwe
chigadzirwa muUK, Germany neSpain. Kumwe kutangwa kwakatevera, nekunyoreswa mune anopfuura makumi matanhatu nepfumbamwe
nyika ne 2018. Pakazosvika 2019, the
10-gore yegore rejeon, zvimwe
majekiseni anodarika miriyoni imwe akanga atengeswa
pasi rose. Asi nyaya yebudiriro haina kugumira ipapo, nenzvimbo itsva yekugadzira muNetherlands ichitanga
kugadzirwa muna 2020
REJEON PCL PRODUCT Detail
1ml/chidimbu
Gamuchira OEM yakagadzirirwa kurongedza
